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Indiana University will invest $300 million over the next five years in a Grand Challenges research program aimed at solving some of the planet’s most urgent problems. Up to five large-scale research projects will be selected for funding, based on their potential impact on the state of Indiana, its economy and the campus. But the projects, such as those related to international water supply issues, energy availability, infectious diseases and climate change, will have global implications. They’ll involve interdisciplinary research and new partnerships with nonprofits, industry and government. The university announced Wednesday that it is seeking preliminary proposals from faculty teams for the first two Grand Challenge grants, to begin next year. The initiative will be paid for through a combination of donations, existing university funds and reallocated planned expenditures, and other sources.